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Targets Recommended: Apoptosis Autophagy

16

抑制剂 & 化合物

5

天然产物

22

重组蛋白

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Cat. No. Product Name Target Signaling Pathways
T5181 CA-5f

Apoptosis; Autophagy Apoptosis; Autophagy
CA-5f 是晚期巨自噬/自噬抑制剂,通过抑制自噬体-溶酶体融合起作用。它能够增加监控自噬的标记物 LC3B-II 和 SQSTM1 蛋白水平,促进 ROS 的产生,具有抗肿瘤活性。
T5856 Barnidipine hydrochloride

盐酸巴尼地平,YM-09730-5 hydrochloride,Mepirodipine (hydrochloride)

Calcium Channel Membrane transporter/Ion channel; Metabolism
Barnidipine hydrochloride (YM-09730-5 hydrochloride) 是一种二氢吡啶类钙通道阻滞剂,对 CaA 受体具有选择性作用。它是一种抗高血压药物,通过减少其血管扩张作用继发的外周血管阻力起作用。
T7550 Barnidipine

YM-09730-5(Free base),(4S)-2,6-二甲基-4-(间硝基苯基)-1,4-二氢吡啶-3,5-二羧酸 (3S)-1-苄基-3-吡咯烷基-甲基酯,Mepirodipine

Calcium Channel Membrane transporter/Ion channel; Metabolism
Barnidipine (YM-09730-5(Free base)) 是一种二氢吡啶类钙通道阻滞剂,对 CaA 受体具有选择性作用。它是一种抗高血压药物,通过减少其血管扩张作用继发的外周血管阻力起作用。
T21029 Norfluoxetine Hydrochloride

Norfluoxetine HCl,去甲氟西汀

Others Others
Norfluoxetine Hydrochloride (Norfluoxetine HCl) 是氟西汀的活性代谢物。氟西汀是一种抗抑郁药。
T1824 TGR5 Receptor Agonist

GPCR19 GPCR/G Protein
TGR5 Receptor Agonist 是一种TGR5(GPCR19)激动剂。
T16564 PPADS tetrasodium

P2X Receptor; Na+/Ca2+ Exchanger Membrane transporter/Ion channel; Neuroscience
PPADS tetrasodiuma 是一种有效的 P2X 受体拮抗剂,也是是豚鼠气道平滑肌 Na/Ca²⁺ 交换逆模式的抑制剂,对谷氨酸/NMDA毒性有神经保护作用。PPADS tetrasodiuma 抑制 P2X1、P2X-2、P2X-3 和 P2X-5
T21509 CA 074

Cysteine Protease Proteases/Proteasome
CA 074 是一种高效的组织蛋白酶B (cathepsin B) 抑制剂, Ki 值为2 to 5 nM。CA 074 抑制灵长类动物缺血性海马神经元死亡,可减轻 SJL/J 小鼠诱导的实验性自身免疫性脑脊髓炎的视网膜病变和视神经炎。
T35251 YK-5-252

YK 5 252,YK5-252,YK-5252

YK-5-252 is a dual action combretastatin A-4 (CA-4) prodrug which releases CA-4 through a disulfide bond cleavage mechanism and contains a near-infrared (NIR) fluorophore.
T31573 DPX-3778

DPX-3778 is the triethanolamine salt of 3-(p-chlorophenyl)-6-methoxy-s-triazine-2,4(1H,3H) dione, at concentrations of 0.124-2.48 μM enhanced ca. 4-5-fold the proliferation of tobacco (Nicotiana tabacum L. cv. Wisconsin 38) callus cultured in the presence
T60602 hCAIX/XII-IN-5

hCAIX/XII-IN-5 (Coumarin 9a) 是一种碳酸酐酶 (CA) 抑制剂,具有出色的 hCA IX/XII 选择性,对 hCA I 和 hCA II 的Ki 值分别为 93.9 和 85.7 nM。hCAIX/XII-IN-5 对癌细胞具有抗增殖活性,可延迟细胞周期并诱导细胞凋亡。
T4186 AC-264613

AC264613

Protease-activated Receptor GPCR/G Protein
AC-264613 是一种选择性蛋白酶激活受体 (PAR-2) 激动剂,pEC50为 7.5
T28618 RS-93522

RS 93522

RS-93522 is an antagonist of calcium channel. RS-93522 had the additional property of inhibiting phosphodiesterase activity in myocardial homogenates (IC50 = 1.6 x 10(-5)M), the potency and efficacy of phosphodiesterase inhibition was similar to that for
T60526 N-Salicyloyltryptamine

N-Salicyloyltryptamine(STP) 是一种色胺类似物,具有抗惊厥、抗炎、镇痛和血管舒张的作用。N-Salicyloyltryptamine 作为电压依赖性离子通道(包括Na+、Ca2+、K+离子通道)抑制剂,可抑制 K+电流,IC50值为 34.6 μM ( /to)。
T72213 Efonidipine hydrochloride

NZ-105 hydrochloride

Efonidipine(NZ-105)盐酸盐是T 型和L 型钙离子通道双重阻断剂。
T37847 Zonisamide-13C2,15N

Zonisamide-13C2,15N

Zonisamide-13C2,15N is intended for use as an internal standard for the quantification of zonisamide by GC- or LC-MS. Zonisamide is an antiepileptic agent.1 It selectively inhibits the repeated firing of sodium channels (IC50 = 2 μg/ml) in mouse embryo spinal cord neurons and inhibits spontaneous channel firing when used at concentrations greater than 10 μg/ml.2 In rat cerebral cortex neurons, zonisamide (1-1,000 μM) inhibits T-type calcium channels with a maximum reduction of 60% of the calcium...
T78705 COX-2-IN-30

COX Immunology/Inflammation; Neuroscience
COX-2-IN-30 是苯磺酰胺衍生的口服活性 COX/5-LOX 双重抑制剂,其 IC50 值为 COX 同源物为 49 nM、5-LOX 同源物为 10.4 μM。此化合物还能纳摩尔级别 Ki 值抑制 hCA IX 与 hCA XII 亚型。COX-2-IN-30 具备镇痛、抗炎、致溃疡作用,不引发急性胃部反应。

化合物

CA-5f
Cat.No: T5181
Synonym:
Target: Apoptosis, Autophagy
Barnidipine hydrochloride
Cat.No: T5856
Synonym: 盐酸巴尼地平,YM-09730-5 hydrochloride,Mepirodipine (hydrochloride)
Target: Calcium Channel
Barnidipine
Cat.No: T7550
Synonym: YM-09730-5(Free base),(4S)-2,6-二甲基-4-(间硝基苯基)-1,4-二氢吡啶-3,5-二羧酸 (3S)-1-苄基-3-吡咯烷基-甲基酯,Mepirodipine
Target: Calcium Channel
Norfluoxetine Hydrochloride
Cat.No: T21029
Synonym: Norfluoxetine HCl,去甲氟西汀
Target: Others
TGR5 Receptor Agonist
Cat.No: T1824
Synonym:
Target: GPCR19
PPADS tetrasodium
Cat.No: T16564
Synonym:
Target: P2X Receptor, Na+/Ca2+ Exchanger
CA 074
Cat.No: T21509
Synonym:
Target: Cysteine Protease
YK-5-252
Cat.No: T35251
Synonym: YK 5 252,YK5-252,YK-5252
Target:
DPX-3778
Cat.No: T31573
Synonym:
Target:
hCAIX/XII-IN-5
Cat.No: T60602
Synonym:
Target:
AC-264613
Cat.No: T4186
Synonym: AC264613
Target: Protease-activated Receptor
RS-93522
Cat.No: T28618
Synonym: RS 93522
Target:
N-Salicyloyltryptamine
Cat.No: T60526
Synonym:
Target:
Efonidipine hydrochloride
Cat.No: T72213
Synonym: NZ-105 hydrochloride
Target:
Zonisamide-13C2,15N
Cat.No: T37847
Synonym: Zonisamide-13C2,15N
Target:
COX-2-IN-30
Cat.No: T78705
Synonym:
Target: COX
Cat. No. Product Name Target Signaling Pathways
T3915 Ginsenoside Ro

人参皂苷Ro,Chikusetsusaponin 5,Polysciasaponin P3,人参皂苷 Ro,Chikusetsusaponin V

Calcium Channel; Reductase; Prostaglandin Receptor Endocrinology/Hormones; GPCR/G Protein; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism
Ginsenoside Ro (Chikusetsusaponin V) 能降低 TXA2产量,较弱降低 COX-1 和 TXAS 活性,具有 Ca2+拮抗剂的抗血小板作用,IC50为 155 μM。
T4S2326 Cornuside

7-Galloylsecologanol,7-O-Galloylsecologanol,山茱萸新苷,Comuside

ERK; p38 MAPK; NF-κB; JNK MAPK; NF-κB
Cornuside (Comuside) 是从山茱萸的果实中分离出的环烯醚萜苷,可用于炎症疾病的研究和促进血液循环。 它通过下调 MAPK 和 NF-κB 信号通路抑制肥大细胞介导的过敏反应,用于炎性过敏性疾病中的潜能。
TN3126 5-Methoxyisolariciresinol

Others Others
(+)-5-Methoxyisolariciresinol displays significant antioxidant activities, with the IC(50) value in the range of ca. 42 to 49 microg/ml.
TN6458 Acetylshikonin

Acetylshikonin can effectively inhibit tumor cells, it can be used to treat hepatocellular carcinoma cells expressing hepatitis B virus X protein (HBX) by inducing ER stress , an oncoprotein from hepatitis B virus. Acetylshikonin inhibits the production of eicosanoid, is due to the attenuation of cytosolic phospholipase A(2) membrane recruitment via the decrease in [Ca(2+)](i) and to the blockade of cyclooxygenase and 5-lipoxygenase activity.
TN4624 Nantenine

Others Others
Nantenine is an acetylcholinesterase inhibitor, it functions as an effective antagonist against a wide range of MDMA-induced effects in mice. Nantenine has anticonvulsant effect, which seems attributable to its stimulation and the resultant decrease of Ca

天然产物

Ginsenoside Ro
Cat.No: T3915
Synonym: 人参皂苷Ro,Chikusetsusaponin 5,Polysciasaponin P3,人参皂苷 Ro,Chikusetsusaponin V
Target: Calcium Channel, Reductase, Prostaglandin Receptor
Cornuside
Cat.No: T4S2326
Synonym: 7-Galloylsecologanol,7-O-Galloylsecologanol,山茱萸新苷,Comuside
Target: ERK, p38 MAPK, NF-κB, JNK
5-Methoxyisolariciresinol
Cat.No: TN3126
Synonym:
Target: Others
Acetylshikonin
Cat.No: TN6458
Synonym:
Target:
Nantenine
Cat.No: TN4624
Synonym:
Target: Others
Cat. No. Product Name Species Expression System
TMPY-01877 CA5A Protein, Human, Recombinant (His)

CA5,GS1-21A4.1,CA5AD,

Human E. coli
Carbonic anhydrase 5A, mitochondrial, also known as Carbonate dehydratase VA, Carbonic anhydrase VA, CA-VA and CA5A, is a member of thealpha-carbonic anhydrase family. Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes first discovered in 1933 that catalyze the reversible hydration of carbon dioxide. CAs participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospi...
TMPY-05748 CD45 Protein, Human, Recombinant (aa 26-577, His)

L-CA,T200,LCA,B220,protein tyrosine phosph...

Human HEK293 Cells
CD45 Protein, Human, Recombinant (aa 26-577, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 62.2 kDa and the accession number is P08575-3.
TMPY-05308 CD45 Protein, Human, Recombinant (aa 1-529, His)

GP180,B220,L-CA,protein tyrosine phosphatase, recep...

Human HEK293 Cells
CD45 Protein, Human, Recombinant (aa 1-529, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 57.4 kDa and the accession number is P08575-5.
TMPH-01038 CA5A Protein, Human, Recombinant

Carbonic anhydrase VA,Carbonic anhydrase <...

Human HEK293 Cells
Reversible hydration of carbon dioxide. Low activity. CA5A Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 30.6 kDa and the accession number is P35218.
TMPY-03270 CD45 Protein, Mouse, Recombinant (aa 453-1152, His & GST)

Ly-5,CD45R,Lyt-4,T200,loc,protein tyrosine...

Mouse Baculovirus Insect Cells
CD45 Protein, Mouse, Recombinant (aa 453-1152, His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 108.2 kDa and the accession number is AAA39458.1.
TMPY-04277 CD45 Protein, Mouse, Recombinant (hFc)

Cd45,protein tyrosine phosphatase, receptor type, C...

Mouse HEK293 Cells
CD45 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 71.7 kDa and the accession number is P06800-6.
TMPY-03468 CD45 Protein, Mouse, Recombinant (aa 453-1152)

loc,Lyt-4,protein tyrosine phosphatase, receptor type, C,T20...

Mouse Baculovirus Insect Cells
CD45 Protein, Mouse, Recombinant (aa 453-1152) is expressed in Baculovirus insect cells. The predicted molecular weight is 81 kDa and the accession number is AAA39458.1.
TMPK-00447 CD45 Protein, Human, Recombinant (aa 26-577, hFc)

CD45,CD45R,LCA,PTPRC,L-CA

Human HEK293 Cells
PTPRC (also known as CD45),T cells require the protein tyrosine phosphatase CD45 to detect and respond to antigen because it activates the Src family kinase Lck, which phosphorylates the T cell antigen receptor (TCR) complex. CD45 ativates Lck by opposing the negative regulatory kinase Csk. Paradoxically, CD45 has also been implicated in suppressing TCR signaling by dephosphorylating the same signaling motifs within the TCR complex upon which Lck acts. CD45 Protein, Human, Recombinant (aa 26-577...
TMPK-00423 CD45 Protein, Human, Recombinant (His & Avi)

CD45R,LY5,EC 3.1.3.48,B220,CD45,T...

Human HEK293 Cells
PTPRC (also known as CD45),T cells require the protein tyrosine phosphatase CD45 to detect and respond to antigen because it activates the Src family kinase Lck, which phosphorylates the T cell antigen receptor (TCR) complex. CD45 ativates Lck by opposing the negative regulatory kinase Csk. Paradoxically, CD45 has also been implicated in suppressing TCR signaling by dephosphorylating the same signaling motifs within the TCR complex upon which Lck acts. CD45 Protein, Human, Recombinant (His & Avi...
TMPK-00424 CD45 Protein, Human, Recombinant (His & Avi), Biotinylated

LCA,LY5,EC 3.1.3.48,CD45,L-CA...

Human HEK293 Cells
PTPRC (also known as CD45),T cells require the protein tyrosine phosphatase CD45 to detect and respond to antigen because it activates the Src family kinase Lck, which phosphorylates the T cell antigen receptor (TCR) complex. CD45 ativates Lck by opposing the negative regulatory kinase Csk. Paradoxically, CD45 has also been implicated in suppressing TCR signaling by dephosphorylating the same signaling motifs within the TCR complex upon which Lck acts. CD45 Protein, Human, Recombinant (His & Avi...
TMPY-00711 CD45 Protein, Human, Recombinant (hFc)

GP180,L-CA,LY5,T200,protein tyrosine phosp...

Human HEK293 Cells
CD45 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 71.1 kDa and the accession number is P08575-4.
TMPJ-00410 CD45R0 Protein, Human, Recombinant (His)

CD45 antigen,L-CA,protein tyrosine phospha...

Human HEK293 Cells
CD45R0 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 80-120 KDa and the accession number is P08575-4.
TMPJ-00794 CD45 Protein, Mouse, Recombinant (His)

CD45,receptor-type tyrosine-protein phosphatase C,C...

Mouse HEK293 Cells
CD45 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 120-160 KDa and the accession number is P06800.
TMPJ-00808 CD45RA Protein, Human, Recombinant (His)

PTPRC,CD45R,CD45,LCA,protein tyro...

Human HEK293 Cells
CD45RA Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 100-135 KDa and the accession number is P08575-8.
TMPH-01024 Calbindin Protein, Human, Recombinant (His)

Vitamin D-dependent calcium-binding protein, avian-...

Human P. pastoris (Yeast)
Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase. Calbindin Protein, Human, Recombinant (His) is expressed in yeast with C-6xHis tag. The predicted molecular weight is 30.8 kDa and the accession number is P05937.
TMPY-05387 SLAMF7 Protein, Human, Recombinant (hFc)

SLAM family member 7,19A,SLAM7,CS1,CD319,CRACC

Human HEK293 Cells
SLAMF7 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 49.1 kDa and the accession number is Q9NQ25-5.
TMPY-04318 GRIK2 Protein, Human, Recombinant (hFc)

GLUR6,EAA4,MRT6,GLR6,glutamate receptor, ionotropic, kainate...

Human HEK293 Cells
GRIK2 (Glutamate Ionotropic Receptor Kainate Type Subunit 2, also known as GluR6) is a Protein Coding gene. The GRIK2 (one of the kainate receptors) gene resides in a genetic linkage region (6q21) associated with bipolar disorder (BPD). The gene coding for GRIK2 has been suggested as a candidate gene for autism based on its localization in the autism-specific region on chromosome 6q21 and the involvement of receptor protein in cognitive functions like learning and memory. GRIK2 belongs to the gl...
TMPY-05547 SLAMF7 Protein, Human, Recombinant (hFc), Biotinylated

CS1,SLAM7,CD319,SLAM family member 7,CRACC,19A

Human HEK293 Cells
SLAMF7 Protein, Human, Recombinant (hFc), Biotinylated is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 49.1 kDa and the accession number is Q9NQ25-5.
TMPJ-00854 ETS1 Protein, Human, Recombinant (His)

V-ets Erythroblastosis Virus E26 Oncogene Homolog 1 (Avian),...

Human E. coli
ETS1 Protein (ETS1) is a nuclear protein that belongs to the ETS family. Members of this family recognize the core consensus DNA sequence GGAA/T in target genes. Proteins function either as transcriptional activators or repressors of numerous genes. They are involved in stem cell development, cell senescence and death, and tumorigenesis. ETS1 is a transcription factor, containing one ETS DNA-binding domain and one PNT (pointed) domain. it has been shown to interact with TTRAP, UBE2I and Death As...
TMPY-05498 SR-BI/SCARB1 Protein, Human, Recombinant (hFc)

HDLQTL6,SR-BI,SRB1,CD36L1,CLA-1,CLA1,scavenger rece...

Human HEK293 Cells
SR-BI/SCARB1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 73.4 kDa and the accession number is Q8WTV0-5.
TMPK-01357 SIRP alpha V5 Protein, Human, Recombinant (His & Avi)

MFR,PTPNS1,P84,BIT,MYD-1,MYD1,SHPS-1,SIRPA,SIRP α,SIRP α V

Human HEK293 Cells
Signal regulatory protein α (SIRPα) is a regulatory membrane glycoprotein from SIRP family expressed mainly by myeloid cells and also by stem cells or neurons.SIRPα acts as inhibitory receptor and interacts with a broadly expressed transmembrane protein CD47 also called the "don´t eat me" signal.
TMPK-01363 SIRP alpha V5 Protein, Human, Recombinant (His & Avi), Biotinylated

SIRP alpha,MFR,PTPNS1,SIRP α V5,P84,SHPS-1,BIT,CD17...

Human HEK293 Cells
Signal regulatory protein α (SIRPα) is a regulatory membrane glycoprotein from SIRP family expressed mainly by myeloid cells and also by stem cells or neurons.SIRPα acts as inhibitory receptor and interacts with a broadly expressed transmembrane protein CD47 also called the "don´t eat me" signal.Cancer cells highly expressed CD47 that activate SIRP α and inhibit macrophage-mediated destruction. SIRP alpha V5 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian c...

重组蛋白

CA5A Protein, Human, Recombinant (His)
Cat.No: TMPY-01877
Species: Human
Expression System: E. coli
CD45 Protein, Human, Recombinant (aa 26-577, His)
Cat.No: TMPY-05748
Species: Human
Expression System: HEK293 Cells
CD45 Protein, Human, Recombinant (aa 1-529, His)
Cat.No: TMPY-05308
Species: Human
Expression System: HEK293 Cells
CA5A Protein, Human, Recombinant
Cat.No: TMPH-01038
Species: Human
Expression System: HEK293 Cells
CD45 Protein, Mouse, Recombinant (aa 453-1152, His & GST)
Cat.No: TMPY-03270
Species: Mouse
Expression System: Baculovirus Insect Cells
CD45 Protein, Mouse, Recombinant (hFc)
Cat.No: TMPY-04277
Species: Mouse
Expression System: HEK293 Cells
CD45 Protein, Mouse, Recombinant (aa 453-1152)
Cat.No: TMPY-03468
Species: Mouse
Expression System: Baculovirus Insect Cells
CD45 Protein, Human, Recombinant (aa 26-577, hFc)
Cat.No: TMPK-00447
Species: Human
Expression System: HEK293 Cells
CD45 Protein, Human, Recombinant (His & Avi)
Cat.No: TMPK-00423
Species: Human
Expression System: HEK293 Cells
CD45 Protein, Human, Recombinant (His & Avi), Biotinylated
Cat.No: TMPK-00424
Species: Human
Expression System: HEK293 Cells
CD45 Protein, Human, Recombinant (hFc)
Cat.No: TMPY-00711
Species: Human
Expression System: HEK293 Cells
CD45R0 Protein, Human, Recombinant (His)
Cat.No: TMPJ-00410
Species: Human
Expression System: HEK293 Cells
CD45 Protein, Mouse, Recombinant (His)
Cat.No: TMPJ-00794
Species: Mouse
Expression System: HEK293 Cells
CD45RA Protein, Human, Recombinant (His)
Cat.No: TMPJ-00808
Species: Human
Expression System: HEK293 Cells
Calbindin Protein, Human, Recombinant (His)
Cat.No: TMPH-01024
Species: Human
Expression System: P. pastoris (Yeast)
SLAMF7 Protein, Human, Recombinant (hFc)
Cat.No: TMPY-05387
Species: Human
Expression System: HEK293 Cells
GRIK2 Protein, Human, Recombinant (hFc)
Cat.No: TMPY-04318
Species: Human
Expression System: HEK293 Cells
SLAMF7 Protein, Human, Recombinant (hFc), Biotinylated
Cat.No: TMPY-05547
Species: Human
Expression System: HEK293 Cells
ETS1 Protein, Human, Recombinant (His)
Cat.No: TMPJ-00854
Species: Human
Expression System: E. coli
SR-BI/SCARB1 Protein, Human, Recombinant (hFc)
Cat.No: TMPY-05498
Species: Human
Expression System: HEK293 Cells
SIRP alpha V5 Protein, Human, Recombinant (His & Avi)
Cat.No: TMPK-01357
Species: Human
Expression System: HEK293 Cells
SIRP alpha V5 Protein, Human, Recombinant (His & Avi), Biotinylated
Cat.No: TMPK-01363
Species: Human
Expression System: HEK293 Cells
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